Omega 3 Fish Oil Research Studies and Articles



There have been over 8,000 scientific studies on the benefits of omega 3 fish oil for your health. We've picked a few of the them here for you to read more about - both mainstream articles as well as scholarly research studies. Search the fish oil research articles by person or by symptom:

By Person:
By Symptom:

Men's health:

Experts Recommend One to Two Grams of Fish Oil Per Day for Heart Health
Men's Fitness Magazine: The Best 5 Supplements for Men

Doctors Recommend Omega-3 For Rebuilding Brian Matter, Helping Heart Health and Relieving Joint Pain
Men's Health Fitness: The Government's Big Fish Story

Studies Prove That Omega-3 Helps Reduce Cholesterol, Irregular Heartbeats, and Protects Against Blood Clots
Discovery Health Network: Eight-Step Plan to Lower Your Cholesterol

Women's Health:

Fish Oil Research Shows It May Help Prevent Breast Cancer in Women
Discovery Health Network: How to Hedge Against Your Risk of Breast Cancer

Omega 3 Helps with Menopause-Related Dry Skin
Discovery Health Network: Solutions for Seven Symptoms of Perimenopause

Omega 3 And Children

BBC: The Durham School Study
In Durham England, a group of more than 100 students from 12 different schools took part in a double-blind placebo-controlled fish oil research study. The children took fish oil supplements with their meals for six months, and the results showed a significant improvement in reading, spelling and behavior, with 44% of the children no longer meeting the clinical criteria for ADHD.

Journal of Developmental and Behavioral Pediatrics: The Effect of Supplementation with Polyunsaturated Fatty Acids and Micronutrients on Learning and Behaviour Problems Associated with Child ADHD
Drs. Sinn and Bryan completed a randomized trial on 104 Australian children aged 7 to 12. In this randomized, placebo-controlled double-blind fish oil research test, significant improvements were found. After 3 months, 30-40% of the students no longer met the clinical diagnostic criteria for ADHD, and after 6 months, that number had risen to 40-50%.

Journal of Attention Disorders: Omega-3/Omega-6 Fatty Acids for Attention Deficit Hyperactivity Disorder: A Randomized Placebo-Controlled Trial in Children and Adolescents In this study, 75 students with ADHD partipated in a fish oil versus placebo trial for six months. After three months, 26% of the students showed a 25% reduction of ADHD symptoms, and after 6 months 47% of all students showed the same improvement.

Journal of Developmental & Behavioural Pediatrics: Attention Deficit Disorder with Hyperactivity In a randomized, placebo-controlled study, 132 children in Australia were given omega 3 supplements or olive oil. Parents reported a strong, positive treament effects against ADHD symptoms of inattention, hyperactivity and impulsivity. Researchers concluded that fish oil may calm children better than Ritalin.

Senior's Health

American Journal of Clinical Nutrition: High Intake of Omega-3 decreases Heart Disease in the Elderly In the Cardiovascular Health Study, adults 65 years of age with higher intakes and levels of omega-3 EPA and DHA had a decrease in the risk of fatal heart disease.  The fish oil research study measured blood levels of EPA and DHA two years before a heart attack and found that those with higher blood levels of these omega-3s had a 70% lower risk of a fatal heart attack.

Archives of Internal Medicine: The Type of Fish, Baked/broiled versus Fried, reduces Strokes in the Elderly To better understand the effects of different fish meals on the risk of stroke in the elderly, 4775 adults ³65 years of age were studied for 12 years.  Adults who consumed broiled or baked fish up to 5 times/week had a 30% lower risk of stroke than intake of fish less than once a month.  Furthermore, consumption of fried fish/fish sandwiches, rich in trans fats, lead to an increase in strokes.

Heart Health

Listen to the Mayo Clicic's Podcast: "Omega-3 Fatty Acids - are they good for your heart?"


Lancet: Large Study in Italy proves Omega-3 effective in people with Heart Disease GISSI Prevenzion Study:  In the famous Italian GISSI fish oil research trial conducted with 11,324 patients who had experienced a myocardial infarction, supplementing ~1g omega-3 (850mg EPA+DHA) per day significantly reduced overall cardiovascular deaths by 30% and risk of sudden death by 45%.  Furthermore, the risk reduction in total mortality and sudden death was observed after 3 and 4 months of supplementation, respectively.


Archives of Internal Medicine: Omega-3s: the Most Effective Therapy against Cardiac Mortality- A group of medical doctors published a review on the effects of different cholesterol lowering therapies, including statins, omega-3, fibrates, resins and niacin, on reducing the risk of mortality. Omega-3 EPA+DHA supplementation was the most effective, reducing cardiac mortality by 32%, whereas statins reduced cardiac mortality by 22%.  Furthermore, the doctors concluded that omega-3s were as effective as fibrates in lowering blood triglyceride levels.


Journal of the American Medical Association High Intakes and Blood Levels of Omega-3 Reduces Heart Attacks In a study of 334 patients with primary cardiac arrest as compared to controls, dietary intake of omega-3 fatty acids, EPA and DHA, reduces the risk of cardiac arrest by 50% compared to no intake.  Furthermore, the people with the highest blood levels of omega-3 had a 70% reduction in the risk of primary cardiac arrest.

Brain Health

Archives of Neurology: Omega-3 from Fish prevent Alzheimer Disease 815 adults aged 65 to 94 years without Alzheimer disease at the start of the trial were studied for 4 years to measure the risk of developing Alzheimer disease.  The results showed that participants who had higher intakes of omega-3s from fish, including DHA, had a 60% reduction in the risk of developing Alzheimer disease.


Archives of Neurology: Omega-3 prevent Cognitive Decline in patients with early Alzheimer’s Disease In a randomized, double-blind fish oil research study, 174 Alzheimer disease (AD) patients supplemented with 2.3 grams of omega-3 EPA+DHA capsules compared to a placebo and mental cognition was measured.  After 6 months, patients with very mild AD did not experience a decline in ‘delayed word recall’ or ‘attention’ as compared to the control group. The study concluded that omega-3s are more effective in preventing AD or in patients with early stage AD.

American Journal of Clinical Nutrition: Low blood level of Omega-3 EPA predicts risk of Dementia A study of 1214 participants without dementia was conducted for 4 years.  Researchers observed that the participants with higher blood levels of omega-3 EPA had a 31% reduced risk of developing dementia.  Furthermore, high blood levels of the omega-6 to omega-3 ratio increased participants risk for dementia, especially in older adults with depression.

Archives of General Psychiatry: A randomized, placebo-controlled double-blind fish oil research study of patients with bipolar disorder found that supplementing their usual treatment with omega-3 fatty acids increased remission time significantly. (Stoll)

Mood and Behaviour

Psychiatry Research: Higher levels of Omega-3 related to lower Mood and Behaviour Variations The association between blood levels of omega-3s and variation in mood, personality and behaviour was measured in adults with high-cholesterol.  After completing a range of mental tests, adults with higher levels of omega-3 EPA and DHA had lower scores of depression and neuroticism.  Higher levels of DHA was also related to lower cognitive impulsivity. 


British Journal of Psychiatry: Omega-3s Improves Well-being and reduces Self-harm A fish oil research study was conducted in a group of patients repeatedly inflicting self-harm.  After supplementation of 2.1 grams of omega 3 EPA+DHA for 12 weeks there was a significant improvement in depression, suicidality and daily stress scores, thus benefiting well-being and reducing suicidal behaviours.


The Australian and New Zealand journal of psychiatry: Omega-3 EPA as effective as Drug Therapy in Major Depressive Disorder In a double-blind fish oil research trial, the effects of 1g of omega-3 EPA, alone or in combination with the anti-depressant drug Fluoxetine (20mg) was studied in 48 patients with major depression.  Supplementing omega-3 EPA was as effective in controlling depressive symptoms as Fluoxetine, whereas the combination of EPA+fluoxetine was most effective.


American Journal of Clinical Nutrition: Omega-3 EPA reduces Depressive symptoms in the Elderly In the Three-City Study, 1390 elderly adults from Bordeaux, France were studied to see the relationship between blood levels of omega-3 and symptoms of depression.  The study concluded that in the elderly, especially those already taking antidepressant medication, higher blood levels of omega-3 EPA was associated with lower severity of depression symptoms.


The Journal of Clinical Psychiatry Studies show that Omega-3s are Antidepressants Low intakes and blood levels of omega-3s has been associated with depression. A review of 10 studies found promising evidence that omega-3s is beneficial in the treatment of depression.  Omega-3s have significant antidepressant effects in patients with depression or with bipolar disorder.


Archives of General Psychiatry: Omega-3 EPA daily treats Depression and more Three doses of omega-3 EPA were tested against placebo in depressed patients to assess the benefits for treating major depressive disorders in this fish oil research study.  Supplementing 1 gram of omega-3 EPA per day for 12 weeks was effective in treating depression with strong benefits in depression, anxiety, sleep, lassitude, libido and suicidality.


The Journal of Clinical Psychiatry: Omega-3s have benefits for Depression during Pregnancy Due to the fetal demands of mothers' omega-3 stores, pregnant women’s levels of omega-3 become depleted and this has been associated with perinatal depression.  A fish oil research study supplementing only omega-3s during pregnancy showed that omega-3s effectively improved mother’s scores on depression tests and concluded that omega-3s have therapeutic benefits in depressed mothers.


British Journal of Psychiatry: Omega-3 EPA helps treat Bipolar Depression A 12-week double blind fish oil research study in 26 participants with bipolar depression, researchers examined the efficacy of omega-3s compared to placebo as adjunctive therapy.  Significant improvements were noted in tests of depression with bipolar participants supplementing either 1 or 2 grams of omega-3 EPA daily as compared to placebo.


The Journal of Clinical Psychiatry: Omega-3 EPA for reducing Bipolar Depression and related symptoms A small study in patients with mild to moderate bipolar depression showed that supplementing 1.5 to 2 grams of omega-3 EPA daily  for at least 1 month resulted in a >50% reduction in the Hamilton Rating Scale for depression.  Furthermore, these bipolar patients did not develop hypomania or manic symptoms.

Nutrition Journal: Omega-3s decrease Irritability in Bipolar patients A fish oil research study was conducted in 37 bipolar patients taking medication on the frequency and severity of experiencing irritability.  Addition of low dose omega-3s (1-2 grams daily) improved signs of irritability above and beyond the medications used by the patients with bipolar disorders.

Eye Health

Archives of Ophthalmology: Increase Omega-3 consumption, decrease Age-related Eye Disease The Age-related Eye Disease Study in 2132 elderly participants examined the role of omega-3 EPA and DHA consumption and the risk of developing sight-threatening forms of age-related macular degeneration (AMD).  People consuming the highest levels of omega-3 EPA and DHA had a significant decrease in the progression of eye diseases and AMD.

Archives of Ophthalmology: High intake of Omega-3 from fish decreases risk of Eye Disease - 2335 Australian adults (>49 years old) participated in the Blue Mountains Eye Study assessing the development of age-related maculopathy (ARM) over 5 years.  Participants consuming fish at least once a week had a 40% decrease risk for early ARM, whereas consumption of fish 3 times a week reduced the development of late ARM by 75%.


Archives of Ophthalmology: More evidence that fish omega-3s reduce risk of Macular Degeneration – A study in 681 twins investigated the relationship between omega-3 and fish intakes and the risk of age-related macular degeneration (AMD).  High omega-3 intakes reduced risk of AMD by 22%.

Joint Health

Studies report that Omega-3s treat Joint Pain in Rheumatoid Arthritis
Pain – A review of 17 fish oil research trials studying the effects of omega-3 supplements for pain relief in patients with rheumatoid arthritis or joint pain was conducted.  The results discovered that supplementing omega-3s for 3-4 months reduced the intensity of joint pain, morning stiffness, number of painful tender joints, and the use of non-steroid anti-inflammatory drugs (NSAIDs).


Scandinavian Journal of Rheumatology: High-dose Omega-3 effective for Arthritis of the Spine As study was conducted in 18 patients with arthritis of the spine, Ankylosing Spondylitis (AS), to see the effectiveness of low-dose versus high dose omega-3 supplementation.  Patients in the high-dose omega-3 fish oil research group experienced a significant decrease in disease activity and severity of symptoms of AS.


Surgical Neurology: Omega-3s as an alternative to NSAIDs for Joint Pain Since non-steroid anti-inflammatory drugs (NSAIDs) can be linked to numerous side effects, the efficacy of omega-3 fish oil as an anti-inflammatory was investigated in 250 patients with neck and back pain.  After supplementing a minimum of 1.2 grams of omega-3 EPA+DHA daily, 59% of patients stopped taking their NSAIDs for pain, 60% of patients reported improvements in overall and joint pain, and 88% continued to take omega-3s.  Furthermore, no side effects from omega-3s were reported in this fish oil research study.


Skin and Hair Health

New Research Shows Increasing Omega 3 EPA Makes Skin Look Better; Reduces Photoaging Damage
Journal of Lipid Research, 2005 Abstract

Omega 3 Gives You Healthy Scalp and Shiny Hair
WebMD: Top Foods For Healthy Hair